Heterochromatin is defined as a chromosomal domain harboring repressive H3K9me2/3 or
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …

Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …

The genetic material encoded on X and Y chromosomes provides the foundation by which
biological sex differences are established. Epigenetic regulators expressed on these sex …

Wnt signaling usually functions through a spatial gradient. Localized Wnt3a signaling can
induce the asymmetric division of mouse embryonic stem cells, where proximal daughter …

How histone modifications regulate changes in gene expression during preimplantation
development in any species remains poorly understood. Using CUT&Tag to overcome …

Histone demethylases remove transcriptional repressive marks from histones in the nucleus.
KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine …

Pig cloning by somatic cell nuclear transfer (SCNT) frequently undergoes incomplete
epigenetic remodeling during the maternal-to-zygotic transition, which leads to a significant …

The efficiency of animal artificial breeding in vitro is still low. Oxidative damage is an
important obstacle for in vitro artificial breeding of animals. Melatonin can reduce the degree …

Objective Protamine 1 (PRM1) is specific in sperm and plays essential roles in fertilization,
also a member of cancer testis antigen (CTA) family. This study aims to summarize the …

Studies on the effects of transcriptional memory on clone reprogramming in mammals are
limited. In the present study, we observed higher levels of active histone H3 lysine 4 …