The human history has witnessed the rapid development of technologies such as high-
throughput sequencing and mass spectrometry that led to the concept of 'omics' and …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Advances in single-cell isolation and barcoding technologies offer unprecedented
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …

The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …

Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

Liquid biopsies, in particular, analysis of cell-free DNA (cfDNA), have emerged as a
promising noninvasive diagnostic approach in oncology. Abnormal distribution of DNA …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

High-throughput technologies have revolutionized medical research. The advent of
genotyping arrays enabled large-scale genome-wide association studies and methods for …