Adipokines are biologically active factors secreted by adipose tissue that act on local and
distant tissues through autocrine, paracrine, and endocrine mechanisms. However …

In this review, we delve into the intricate relationship between white adipose tissue (WAT)
remodeling and metabolic aspects in obesity, with a specific focus on individuals with …

Background Intrahepatic triacylglycerol (liver TG) content is associated with hepatic insulin
resistance and dyslipidemia. Liver TG content can be modulated within days under …

In contrast to the well-defined biological feedback loops controlling glucose, the
mechanisms by which the body responds to changes in fatty acid availability are less clearly …

Abstract Growth differentiation factor 15 (GDF15) is a cell stress-response cytokine within the
transforming growth factor-β (TGFβ) superfamily. It is known to exert diverse effects on many …

Infections are often accompanied by weight loss caused by alterations in host behavior and
metabolism, also known as sickness behaviors. Recent studies have revealed that sickness …

Temporomandibular joint osteoarthritis (TMJ-OA) is a common disease often accompanied
by pain, seriously affecting physical and mental health of patients. Abnormal innervation at …

The chronic inflammation present in aged individuals is generally depicted as a detrimental
player for longevity. Here, it is discussed several beneficial effects associated with the …

Abstract Growth differentiation factor 15 (GDF15) is a member of the transforming growth
factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of …

Aim Growth differentiation factor 15 (GDF15) is a stress response cytokine that has been
proposed as a relevant metabolic hormone. Descriptive studies have shown that plasma …