Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

Membrane proteins mediate processes that are fundamental for the flourishing of biological
cells. Membrane-embedded transporters move ions and larger solutes across membranes; …

The voltage-gated potassium (Kv) channels, encoded by 40 genes, repolarize all electrically
excitable cells, including plant, cardiac, and neuronal cells. Although these genes were fully …

N-type voltage-gated calcium (Ca V) channels mediate Ca 2+ influx at presynaptic terminals
in response to action potentials and play vital roles in synaptogenesis, release of …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

Ion channels and G protein–coupled receptors (GPCRs) are regulated by lipids in their
membrane environment. Structural studies combined with biophysical and molecular …

Voltage-gated potassium (Kv) channels contain voltage-sensing (VSD) and pore-gate (PGD)
structural domains. During voltage-dependent gating, conformational changes in the two …

Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for
therapy and mainly involves a classic gating mechanism that augments the native voltage …

Neural circuits are formed and refined during childhood, including via critical changes in
neuronal excitability. Here, we investigated the ontogeny of striatal intrinsic excitability. We …