Pathogenesis of human cytomegalovirus in the immunocompromised host

P Griffiths, M Reeves - Nature Reviews Microbiology, 2021 - nature.com
Human cytomegalovirus (HCMV) is a herpesvirus that infects~ 60% of adults in developed
countries and more than 90% in developing countries. Usually, it is controlled by a vigorous …

Immunobiology of human cytomegalovirus: from bench to bedside

T Crough, R Khanna - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Quantitative temporal viromics: an approach to investigate host-pathogen interaction

MP Weekes, P Tomasec, EL Huttlin, CA Fielding… - Cell, 2014 - cell.com
A systematic quantitative analysis of temporal changes in host and viral proteins throughout
the course of a productive infection could provide dynamic insights into virus-host …

Genetic content of wild-type human cytomegalovirus

A Dolan, C Cunningham, RD Hector… - Journal of General …, 2004 - microbiologyresearch.org
The genetic content of wild-type human cytomegalovirus was investigated by sequencing
the 235 645 bp genome of a low passage strain (Merlin). Substantial regions of the genome …

Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer?

C SÖDERBERG‐NAUCLÉR - Journal of internal medicine, 2006 - Wiley Online Library
Human cytomegalovirus (HCMV) is a herpes virus that infects and is carried by 70–100% of
the world's population. During its evolution, this virus has developed mechanisms that allow …

Modulation of innate and adaptive immunity by cytomegaloviruses

R Berry, GM Watson, S Jonjic… - Nature reviews …, 2020 - nature.com
The coordinated activities of innate and adaptive immunity are critical for effective protection
against viruses. To counter this, some viruses have evolved sophisticated strategies to …

[HTML][HTML] The 'indirect'effects of cytomegalovirus infection

RB Freeman Jr - American Journal of Transplantation, 2009 - Elsevier
Cytomegalovirus (CMV) remains the most important infection in the immunocompromized
host even in the era of effective therapy. CMV is usually acquired early in life and can be …

Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion

ES Mocarski - Trends in microbiology, 2002 - cell.com
Human cytomegalovirus (CMV) remains the major infectious cause of birth defects as well
as an important opportunistic pathogen. Individuals infected with CMV mount a strong …

Viral immune evasion: a masterpiece of evolution

MT Vossen, EM Westerhout, C Söderberg-Nauclér… - Immunogenetics, 2002 - Springer
Coexistence of viruses and their hosts imposes an evolutionary pressure on both the virus
and the host immune system. On the one hand, the host has developed an immune system …

Reevaluation of human cytomegalovirus coding potential

E Murphy, I Rigoutsos, T Shibuya… - Proceedings of the …, 2003 - National Acad Sciences
The Bio-Dictionary-based Gene Finder was used to reassess the coding potential of the
AD169 laboratory strain of human cytomegalovirus and sequences in the Toledo strain that …