Targeting biomolecular condensation and protein aggregation against cancer

JL Silva, D Foguel, VF Ferreira, TCRG Vieira… - Chemical …, 2023 - ACS Publications
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Aducanumab therapy to treat Alzheimer's disease: a narrative review

SA Beshir, AM Aadithsoorya, A Parveen… - International Journal …, 2022 - Wiley Online Library
Background. Aducanumab, a new monoclonal antibody that targets β‐amyloid aggregates,
has been granted conditional approval by the US FDA for treatment of mild Alzheimer's …

Machine learning and novel biomarkers for the diagnosis of Alzheimer's disease

CH Chang, CH Lin, HY Lane - International journal of molecular sciences, 2021 - mdpi.com
Background: Alzheimer's disease (AD) is a complex and severe neurodegenerative disease
that still lacks effective methods of diagnosis. The current diagnostic methods of AD rely on …

Variation in Phytochemical, Antioxidant and Volatile Composition of Pomelo Fruit (Citrus grandis (L.) Osbeck) during Seasonal Growth and Development

AK Gupta, S Dhua, PP Sahu, G Abate, P Mishra… - Plants, 2021 - mdpi.com
Citrus fruits exhibit a high level of different phytoconstituents, of which the changes in the
different parts of the fruit during ripening have not been thoroughly studied yet. Thus, in this …

The bright side of psychedelics: latest advances and challenges in neuropharmacology

A Mastinu, M Anyanwu, M Carone, G Abate… - International Journal of …, 2023 - mdpi.com
The need to identify effective therapies for the treatment of psychiatric disorders is a
particularly important issue in modern societies. In addition, difficulties in finding new drugs …

Predicting Alzheimer's disease CSF core biomarkers: a multimodal Machine Learning approach

AM Gaeta, M Quijada-López, F Barbé… - Frontiers in Aging …, 2024 - frontiersin.org
Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Current
core cerebrospinal fluid (CSF) AD biomarkers, widely employed for diagnosis, require a …

The road to personalized medicine in Alzheimer's disease: the use of artificial intelligence

A Silva-Spínola, I Baldeiras, JP Arrais, I Santana - Biomedicines, 2022 - mdpi.com
Dementia remains an extremely prevalent syndrome among older people and represents a
major cause of disability and dependency. Alzheimer's disease (AD) accounts for the …

Role of hydrazine-related chemicals in cancer and neurodegenerative disease

PS Spencer, GE Kisby - Chemical Research in Toxicology, 2021 - ACS Publications
Hydrazine-related chemicals (HRCs) with carcinogenic and neurotoxic potential are found in
certain mushrooms and plants used for food and in products employed in various industries …

Post-translational Modifications of the p53 Protein and the Impact in Alzheimer's Disease: A Review of the Literature

JS Clark, R Kayed, G Abate, D Uberti… - Frontiers in Aging …, 2022 - frontiersin.org
Our understanding of Alzheimer's disease (AD) pathogenesis has developed with several
hypotheses over the last 40 years, including the Amyloid and Tau hypotheses. More …

Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis

Y Yao, D Guo, TS Lu, FL Liu, SH Huang, MQ Diao… - Psychiatry …, 2024 - Elsevier
We aim to systematically review and meta-analyze the effectiveness and safety of
psychedelics [psilocybin, ayahuasca (active component DMT), LSD and MDMA] in treating …