Current evidence suggests that activation of glial and immune cells leads to increased
production of proinflammatory mediators, creating a neuroinflammatory state …

Pain is the leading symptom for most individuals with osteoarthritis (OA), a complex
condition marked by joint discomfort. Recently, the dynamic interplay between the nervous …

In dorsal root ganglia (DRG), macrophages reside close to sensory neurons and have
largely been explored in the context of pain, nerve injury, and repair. However, we …

Tumor necrosis factor α (TNF-α) is a major pro-inflammatory cytokine, important in many
diseases, that sensitizes nociceptors through its action on a variety of ion channels …

Macrophage recruitment to the injured nerve initiates a cascade of events, including myelin
debris clearance and nerve trophic factor secretion, which contribute to proper nerve tissue …

Dorsal root ganglion (DRG) toxicity has been consistently reported as a potential safety
concern after delivery of adeno-associated viruses (AAVs) containing gene-replacement …

Macrophages and satellite glial cells are found between injured and uninjured neurons in
the lumbar dorsal root ganglia (DRG). We explored the mechanism of neuro‐immune and …

Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory
mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types …

Current treatments for chronic pain have limited efficacy and significant side effects,
warranting research on alternative strategies for pain management. One approach involves …

Dry eye disease (DED) is characterized by a dysfunctional tear film in which the corneal
epithelium and its abundant nerves are affected by ocular desiccation and inflammation …