Autoimmune pre-disease

K Bieber, JE Hundt, X Yu, M Ehlers, F Petersen… - Autoimmunity …, 2023 - Elsevier
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Targeting ferroptosis as a vulnerability in pulmonary diseases

L Yang, L Cao, X Zhang, B Chu - Cell Death & Disease, 2022 - nature.com
Ferroptosis is an iron-dependent regulated cell death marked by excessive oxidative
phospholipids (PLs). The polyunsaturated fatty acids-containing phospholipids (PUFA-PLs) …

Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease

G De Rubis, KR Paudel, L Corrie, S Mehndiratta… - Naunyn-Schmiedeberg's …, 2024 - Springer
Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the
leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic …

Bispecific antibodies increase the therapeutic window of CD40 agonists through selective dendritic cell targeting

R Salomon, H Rotem, Y Katzenelenbogen, A Weiner… - Nature cancer, 2022 - nature.com
Therapeutic use of agonistic anti-CD40 antibodies is a potentially powerful approach for
activation of the immune response to eradicate tumors. However, the translation of this …

Agarwood oil nanoemulsion attenuates cigarette smoke-induced inflammation and oxidative stress markers in BCi-NS1. 1 airway epithelial cells

G De Rubis, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory
disease characterized by frequent exacerbations and symptoms such as cough and …

Identification of Smoking‐Associated Transcriptome Aberration in Blood with Machine Learning Methods

FM Huang, QL Ma, JX Ren, JR Li… - BioMed research …, 2023 - Wiley Online Library
Long‐term cigarette smoking causes various human diseases, including respiratory
disease, cancer, and gastrointestinal (GI) disorders. Alterations in gene expression and …

An update on the role of Nrf2 in respiratory disease: molecular mechanisms and therapeutic approaches

J Lee, J Jang, SM Park, SR Yang - International Journal of Molecular …, 2021 - mdpi.com
Nuclear factor erythroid 2-related factor (Nrf2) is a transcriptional activator of the cell
protection gene that binds to the antioxidant response element (ARE). Therefore, Nrf2 …

Inflammation-mediated matrix remodeling of extracellular matrix-mimicking biomaterials in tissue engineering and regenerative medicine

M Xu, T Su, X Jin, Y Li, Y Yao, K Liu, K Chen, F Lu… - Acta Biomaterialia, 2022 - Elsevier
Extracellular matrix (ECM)-mimicking biomaterials are considered effective tissue-
engineered scaffolds for regenerative medicine because of their biocompatibility …

[PDF][PDF] Role of oxidative stress in the pathogenesis of COPD

F Nucera, S Mumby, KR Paudel, V Dharwal… - Minerva …, 2022 - opus.lib.uts.edu.au
Chronic inhalation of cigarette smoke is a prominent cause of chronic obstructive pulmonary
disease (COPD) and provides an important source of exogenous oxidants. In addition …

Unravelling the therapeutic potential of nano-delivered functional foods in chronic respiratory diseases

DD Clarence, KR Paudel, B Manandhar, SK Singh… - Nutrients, 2022 - mdpi.com
Chronic inflammation of the respiratory tract is one of the most concerning public health
issues, as it can lead to chronic respiratory diseases (CRDs), some of which are more …