Novel treatment approach for aspergilloses by targeting germination

K Verburg, J van Neer, M Duca, H de Cock - Journal of Fungi, 2022 - mdpi.com
Germination of conidia is an essential process within the Aspergillus life cycle and plays a
major role during the infection of hosts. Conidia are able to avoid detection by the majority of …

Transcription in fungal conidia before dormancy produces phenotypically variable conidia that maximize survival in different environments

F Wang, P Sethiya, X Hu, S Guo, Y Chen, A Li… - Nature …, 2021 - nature.com
Fungi produce millions of clonal asexual conidia (spores) that remain dormant until
favourable conditions occur. Conidia contain abundant stable messenger RNAs but the …

Fungal priming: prepare or perish

E Harish, N Osherov - Journal of Fungi, 2022 - mdpi.com
Priming (also referred to as acclimation, acquired stress resistance, adaptive response, or
cross-protection) is defined as an exposure of an organism to mild stress that leads to the …

Functional genomic and biochemical analysis reveals pleiotropic effect of Congo red on Aspergillus fumigatus

Z Liu, S Raj, N Van Rhijn, M Fraczek, JP Michel… - MBio, 2021 - Am Soc Microbiol
Inhibition of fungal growth by Congo red (CR) has been putatively associated with specific
binding to β-1, 3-glucans, which blocks cell wall polysaccharide synthesis. In this study, we …

Phagolysosomal Survival Enables Non-lytic Hyphal Escape and Ramification Through Lung Epithelium During Aspergillus fumigatus Infection

C Seidel, SD Moreno-Velásquez… - Frontiers in …, 2020 - frontiersin.org
Aspergillus fumigatus is the most important mould pathogen in immunosuppressed patients.
Suboptimal clearance of inhaled spores results in the colonisation of the lung airways by …

Inter- and intra-species heterogeneity in germination of Aspergillus conidia

M Ijadpanahsaravi, WR Teertstra… - Antonie Van …, 2022 - Springer
Aspergilli are among the most abundant fungi worldwide. They degrade organic material
and can be pathogens of plants and animals. Aspergilli spread by forming high numbers of …

Cell wall of Aspergillus fumigatus: Variability and response to stress

JP Latgé - Fungal Biology, 2023 - Elsevier
The fungal cell is surrounded by a thick cell wall which obviously play an essential role in
the protection of the fungus against external aggressive environments. In spite of 50 years of …

Crowdsourced analysis of fungal growth and branching on microfluidic platforms

A Hopke, A Mela, F Ellett, D Carter-House, JF Peña… - PLoS …, 2021 - journals.plos.org
Fungal hyphal growth and branching are essential traits that allow fungi to spread and
proliferate in many environments. This sustained growth is essential for a myriad of …

Multivalent fucosides targeting β-Propeller lectins from lung pathogens with promising anti-Adhesive properties

M Duca, D Haksar, J van Neer… - ACS Chemical …, 2022 - ACS Publications
Fungal and bacterial pathogens causing lung infections often use lectins to mediate
adhesion to glycoconjugates at the surface of host tissues. Given the rapid emergence of …

Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring

F Danion, N van Rhijn, AC Dufour, R Legendre… - Journal of Fungi, 2021 - mdpi.com
Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient
germination of the airborne conidia once they penetrate the respiratory tract. However, the …