Allergens and their associated small molecule ligands—Their dual role in sensitization

M Chruszcz, FT Chew, K Hoffmann‐Sommergruber… - Allergy, 2021 - Wiley Online Library
Many allergens feature hydrophobic cavities that allow the binding of primarily hydrophobic
small‐molecule ligands. Ligand‐binding specificities can be strict or promiscuous. Serum …

New frontiers: precise editing of allergen genes using CRISPR

NF Brackett, A Pomés, MD Chapman - Frontiers in allergy, 2022 - frontiersin.org
Genome engineering with clustered regularly interspaced short palindromic repeats
(CRISPR) technology offers the unique potential for unequivocally deleting allergen genes …

Evolutionary biology and gene editing of cat allergen, Fel d 1

NF Brackett, BW Davis, M Adli, A Pomés… - The CRISPR …, 2022 - liebertpub.com
Allergy to domestic cat affects up to 15% of the population, and sensitization to cat allergen
is associated with asthma. Despite the pervasiveness of cat allergic disease, current …

[HTML][HTML] Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties

B Janssen-Weets, F Kerff, K Swiontek, S Kler… - Frontiers in …, 2022 - frontiersin.org
Allergens from furry animals frequently cause sensitization and respiratory allergic diseases.
Most relevant mammalian respiratory allergens belong either to the protein family of …

Structural and ligand binding analysis of the pet allergens Can f 1 and Fel d 7

J Min, ACY Foo, SA Gabel, L Perera, EF DeRose… - Frontiers in …, 2023 - frontiersin.org
Introduction Pet lipocalins are respiratory allergens with a central hydrophobic ligand-
binding cavity called a calyx. Molecules carried in the calyx by allergens are suggested to …

Human allergy to cats: A review for veterinarians on prevalence, causes, symptoms and control

AH Sparkes - Journal of Feline Medicine and Surgery, 2022 - journals.sagepub.com
Practical relevance: Human allergy to cats affects a substantial and growing proportion of
the global population, and cat allergy is regarded as the third most common cause of human …

[HTML][HTML] Allergies to Allergens from Cats and Dogs: A Review and Update on Sources, Pathogenesis, and Strategies

W An, T Li, X Tian, X Fu, C Li, Z Wang, J Wang… - International Journal of …, 2024 - mdpi.com
Inhalation allergies caused by cats and dogs can lead to a range of discomforting symptoms,
such as rhinitis and asthma, in humans. With the increasing popularity of and care provided …

[HTML][HTML] Molecular diagnosis in cat allergy

FD Popescu, CS Ganea, C Panaitescu… - World Journal of …, 2021 - ncbi.nlm.nih.gov
Domestic cats represent one of the most common sources of indoor allergens. All over the
world, many households own cats, whose allergens are persistent and widespread. Cat …

Role of Small Molecule Ligands in IgE-Mediated Allergy

K Khatri, A O'Malley, C Linn, K Kowal… - Current Allergy and …, 2023 - Springer
Purpose of Review A significant fraction of allergens bind small molecular ligands, and
many of these compounds are classified as lipids. However, in most cases, we do not know …

Mechanistic Insights into the Binding of Boar Salivary Pheromones and Putative Molecule with Receptor Proteins: A Comparative Computational Approach

D Sankarganesh, A Balasundaram, GP Doss C… - ACS …, 2024 - ACS Publications
Precise estrus detection in sows is pivotal in increasing the productivity within the pork
industry. Sows in estrus exhibit exclusive behaviors when exposed to either a live boar or …