Accumulating evidence demonstrates that metabolic changes in the brain associated with
neuroinflammation, oxidative stress, and mitochondrial dysfunction play an important role in …

Age is the main risk factor for a number of human diseases, including neurodegenerative
disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Alzheimer's disease (AD) is the most common cause of dementia worldwide and is
characterised pathologically by the accumulation of amyloid beta and tau protein …

Altered energy metabolism has been implicated both in aging and the pathogenesis of late-
onset Alzheimer's disease (LOAD). However, it is unclear which anomalies are acquired …

Neurodegenerative diseases are characterized by neuronal degeneration as well as
neuroinflammation. While CD38 is strongly expressed in brain cells including neurons …

Late-onset Alzheimer's disease (AD) can, in part, be considered a metabolic disease.
Besides age, female sex and APOE ε4 genotype represent strong risk factors for AD that …

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can
modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we …