Structures and functional diversities of ASFV proteins

G Wang, M Xie, W Wu, Z Chen - Viruses, 2021 - mdpi.com
African swine fever virus (ASFV), the causative pathogen of the recent ASF epidemic, is a
highly contagious double-stranded DNA virus. Its genome is in the range of 170~ 193 kbp …

Medicinal chemistry aspects of uracil containing dUTPase inhibitors targeting colorectal cancer

N Backer, A Kumar, AK Singh, H Singh… - Drug Discovery …, 2023 - Elsevier
Abstract Deoxyuridine-5ʹ-triphosphate nucleotidohydrolase (dUTPase), a vital enzyme in
pyrimidine metabolism, is a prime target for treating colorectal cancer. Uracil shares …

Complete structural predictions of the proteome of african swine fever virus strain georgia 2007

E Spinard, P Azzinaro, A Rai, N Espinoza… - Microbiology …, 2022 - Am Soc Microbiol
Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain
Georgia 2007 | Microbiology Resource Announcements CLOSE This Journal Anywhere …

Porcine alveolar macrophages host proteins interacting with African swine fever virus p72

Z Weng, X Zheng, Y Liang, X Chen, Q Peng… - Frontiers in …, 2024 - frontiersin.org
Introduction African swine fever virus (ASFV) is a highly contagious virus that spreads
rapidly and has a mortality rate of up to 100% in domestic pigs, leading to significant …

Deletion of the ASFV dUTPase Gene E165R from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or …

EA Vuono, E Ramirez-Medina, S Pruitt, A Rai… - Viruses, 2022 - mdpi.com
African swine fever (ASF) is a frequently lethal disease of domestic and wild swine currently
producing a pandemic affecting pig production in Eurasia. The causative agent, ASF virus …

Identification and characterization of a novel epitope of ASFV-encoded dUTPase by monoclonal antibodies

S Zhang, R Wang, X Zhu, J Jin, W Lu, X Zhao, B Wan… - Viruses, 2021 - mdpi.com
Deoxyuridine 5′-triphosphate nucleotidohydrolase (dUTPase) of African swine fever virus
(ASFV) is an essential enzyme required for efficient virus replication. Previous …

Molecular characterization of gut microbiome in weaning pigs supplemented with multi-strain probiotics using metagenomic, culturomic, and metabolomic approaches

WJ Lee, S Ryu, AN Kang, M Song, M Shin, S Oh… - Animal Microbiome, 2022 - Springer
Background Probiotics have been reported to exhibit positive effects on host health,
including improved intestinal barrier function, preventing pathogenic infection, and …

Viral dUTPases: modulators of innate immunity

ME Ariza, B Cox, B Martinez, I Mena-Palomo, GJ Zarate… - Biomolecules, 2022 - mdpi.com
Most free-living organisms encode for a deoxyuridine triphosphate nucleotidohydrolase
(dUTPase; EC 3.6. 1.23). dUTPases represent a family of metalloenzymes that catalyze the …

Structural basis of staphylococcal Stl inhibition on a eukaryotic dUTPase

F Wang, C Liu, C Wang, Y Wang, K Zang… - International Journal of …, 2021 - Elsevier
Abstract dUTPases are key enzymes in all life kingdoms. A staphylococcal repressor protein
(Stl) inhibited dUTPases from multiple species to various extents. Understanding the …

[PDF][PDF] Viral dUTPases: Modulators of Innate Immunity. Biomolecules 2022, 12, 227

ME Ariza, B Cox, B Martinez, I Mena-Palomo, GJ Zarate… - 2022 - academia.edu
Most free-living organisms encode for a deoxyuridine triphosphate nucleotidohydrolase
(dUTPase; EC 3.6. 1.23). dUTPases represent a family of metalloenzymes that catalyze the …