Platelets have a critical role in haemostasis when vessel wall is injured. Platelet receptors
are involved in sequence in this process by slowing platelets down via GPIb/von Willebrand …

This chapter summarizes current ideas about the intracellular signaling that drives platelet
responses to vascular injury. After a brief overview of platelet activation intended to place the …

Pulmonary thrombosis is a significant cause of patient mortality; however, there are no
effective in vitro models of thrombi formation in human lung microvessels that could also …

Thrombosis, or blood clot formation, and its sequelae remain a leading cause of morbidity
and mortality, and recurrent thrombosis is common despite current optimal therapy. Protein …

Hemostatic thrombi formed after a penetrating injury have a distinctive structure in which a
core of highly activated, closely packed platelets is covered by a shell of less-activated …

Interstitial fluid flow within blood clots is a biophysical mechanism that regulates clot growth
and dissolution. Assuming that a clot can be modeled as a porous medium, the physical …

Thrombosis is a deadly malfunctioning of the hemostatic system occurring in numerous
conditions and states, from surgery and pregnancy to cancer, sepsis and infarction. Despite …

Quercetin-3-rutinoside inhibits thrombus formation in a mouse model by inhibiting
extracellular protein disulfide isomerase (PDI), an enzyme required for platelet thrombus …

The severity, course, and outcomes of thrombosis are determined mainly by the size and
location of the thrombus, but studying thrombus structure and composition has been an …

Objective—Platelet-and fibrin-dependent thrombus formation is regulated by blood flow and
exposure of collagen and tissue factor. However, interactions between these blood-borne …