Major depression disorder (MDD) is a debilitating mental illness with significant morbidity
and mortality. Despite the growing number of studies that have emerged, the precise …

Synaptic plasticity confers environmental adaptability through modification of the
connectivity between neurons and neuronal circuits. This is achieved through changes to …

Stressful events promote neurochemical changes that may be involved in the provocation of
depressive disorder. In addition to neuroendocrine substrates (eg corticotropin releasing …

Given the array of biological changes induced by stressors, it is not surprising that these
experiences may provoke a variety of illnesses. Among others things, stressors promote …

Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic
antidepressants gradually exhibit low therapeutic efficiency, especially for patients with …

Anxiety and depression are devastating mental illnesses that are a significant public health
concern. Selective serotonin-reuptake inhibitors are the first-line treatment strategy for these …

Chronic stress increases the risk of developing psychiatric disorders, including mood and
anxiety disorders. Although behavioral responses to repeated stress vary across individuals …

Previous human postmortem brain tissue research has implicated abnormalities of 5-HT
receptor availability in depression and suicide. Although altered abundance of 5-HT 1A, 5 …

MicroRNA (miRNA) expression was measured within frontal cortex of male Holtzman rats
subjected to repeated inescapable shocks at days 1 and 7, tested for learned helplessness …

Major depression is a debilitating disease. Despite a tremendous amount of research, the
molecular mechanisms associated with the etiopathology of major depression are not …