Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Mitochondria and chloroplasts are major sources of free radical generation in living
organisms. Because of this, these organelles require strong protection from free radicals and …

Exposure to chromium (Cr) causes a number of respiratory diseases, including lung cancer
and pulmonary fibrosis. However, there is currently no safe treatment for Cr-induced lung …

Synthesis of melatonin in mitochondria was reported in animals. However, there is no report
on whether plant mitochondria also produce melatonin. Herein, we show that plant …

Abstract Silent information regulator 1 (SIRT 1), a type of histone deacetylase, is a highly
effective therapeutic target for protection against ischemia reperfusion (IR) injury (IRI) …

UV radiation (UVR) induces serious structural and functional alterations in human skin
leading to skin aging and carcinogenesis. Reactive oxygen species are key players in UVR …

Melatonin protects the electron transport chain (ETC) in multiple ways. It reduces levels of·
NO by downregulating inducible and inhibiting neuronal nitric oxide synthases (iNOS …

Oxidative damage is related to aging and a wide range of human disorders. Mitochondria
are in large part responsible for free radical production and they are also main targets of the …

Increasing evidence demonstrates that melatonin has an anti‐inflammatory effect.
Nevertheless, the molecular mechanisms remain obscure. In this study, we investigated the …

Many exogenous (eg, toxins, chemicals, ultraviolet, cigarette smoke) and endogenous (eg,
hyperglycemia, dyslipidemia, cytokines, chemokines) agents disrupt the intracellular …