Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …

The structure of the 68 nt sequence with G-quadruplex forming potential within the hTERT
promoter is disputed. One model features a structure with three stacked parallel G …

We report on higher-order G-quadruplex structures adopted by long promoter sequences
obtained by an iterative integrated structural biology approach. Our approach uses …

Abstract Yin Yang 1 (YY1) is a multifunctional protein with regulatory potential in
tumorigenesis. Ample studies demonstrated the activities of YY1 in regulating gene …

In recent years, an increasing number of reports have been focused on the structure and
biological role of non-canonical nucleic acid secondary structures. Many of these studies …

Circular dichroism (CD) is a phenomenon that arises from the differential absorption of left‐
and right‐handed circularly polarized light, and may be seen with optically active molecules …

Rationale Ion‐pair reversed‐phase liquid chromatography/electrospray ionization mass
spectrometry (IP‐RP‐LC/ESI‐MS) has been widely used for the quality control of …

Molecular silver clusters are optical chromophores, and species with distinct spectra form
with DNA strands. One such hybrid chromophore is a violet cluster bound to repeated C2X …

In this work, we present the case of the G-quadruplex (G4)-forming aptamers we recently
identified for the recognition of HMGB1, protein involved in inflammation, autoimmune …