Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes∼
24 hr rhythms in many behavioral and physiological processes. This system is altered in …

Circadian clocks are encoded by a transcription-translation feedback loop that aligns
energetic processes with the solar cycle. We show that genetic disruption of the clock …

The circadian clock acts at the genomic level to coordinate internal behavioural and
physiological rhythms via the CLOCK–BMAL1 transcriptional heterodimer. Although the …

Life on earth has adapted to the day-night cycle by evolution of internal, so-called circadian
clocks that adjust behavior and physiology to the recurring changes in environmental …

Abstract Rev-Erb-α and Rev-Erb-β are nuclear receptors that regulate the expression of
genes involved in the control of circadian rhythm,, metabolism, and inflammatory responses …

Disruption of the circadian clock exacerbates metabolic diseases, including obesity and
diabetes. We show that histone deacetylase 3 (HDAC3) recruitment to the genome displays …

Introduction The circadian clock is a transcriptional oscillator that is thought to couple
internal energetic processes with the solar cycle. Circadian oscillation in activity of …

The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects
are modest and it has been considered to be a secondary regulator of the cell-autonomous …