Lipids, phospholipids and cholesterol in particular, are the predominant components of the
plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …

Oxidative stress and oxidative damage to tissues are common end points of chronic
diseases, such as atherosclerosis, diabetes, and rheumatoid arthritis. The question …

Reactive oxygen or nitrogen species (ROS/RNS) generated endogenously or in response to
environmental stress have long been implicated in tissue injury in the context of a variety of …

The onset of lipid peroxidation within cellular membranes is associated with changes in their
physiochemical properties and with the impairment of enzymatic functions located in the …

Low molecular weight thiol-containing compounds have an essential role in many
biochemical and pharmacological reactions due to the ease with each they are oxidized …

It has been established that the key metabolic pathways of glycolysis and oxidative
phosphorylation are intimately related to redox biology through control of cell signaling …

Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular
and cellular dysfunction that plays a major role in ageing and most age-related and …

Hydroxy-2-trans-nonenal (4HNE), one of the major end products of lipid peroxidation (LPO),
has been shown to induce apoptosis in a variety of cell lines. It appears to modulate …

This review on recent research advances of the lipid peroxidation product 4-hydroxy-
nonenal (HNE) has four major topics: I. the formation of HNE in various organs and tissues …

Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The reduction
of glucose by the AR-catalyzed polyol pathway has been linked to the development of …