Toxicokinetic (TK) models have been used for decades to estimate concentrations of per-
and polyfluoroalkyl substances (PFAS) in serum. However, model complexity has varied …

Per-and polyfluoroalkyl substances (PFAS) are ubiquitously distributed in the aquatic
environment. They include persistent, mobile, bioaccumulative, and toxic chemicals and it is …

Background: Oral ingestion, inhalation, and skin contact are important exposure routes for
humans to uptake per-and polyfluoroalkyl substances (PFAS). However, nasal and dermal …

Background Toxicokinetic (TK) data needed for chemical risk assessment are not available
for most chemicals. To support a greater number of chemicals, the US Environmental …

Background: Per-and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment
and have been shown to cause various adverse health impacts. In animals, sex-and species …

This study aimed to investigate sex, age, and species differences of perfluorooctanoic acid
(PFOA) using physiologically-based pharmacokinetic (PBPK) models in rats and humans …

Chemical risk assessors use physiologically based pharmacokinetic (PBPK) models to
perform dosimetric calculations, including extrapolations between exposure scenarios …

环境污染物的联合暴露往往会对人类健康产生意想不到的危害. 如何去比较和评估这种危害,
一直以来都是国际社会密切关注的问题. 目前在人体健康风险评估领域使用较多的4 …

The combined exposure to environmental pollutants can result in unanticipated adverse
effects on human health, and how to compare and assess these effects has always been a …

Toxicokinetics describes the absorption, distribution, metabolism, and elimination of
chemicals by the body. Predictions from toxicokinetic models provide key information for …