The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

N Couto, J Wood, J Barber - Free radical biology and medicine, 2016 - Elsevier
In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

Why nature chose selenium

HJ Reich, RJ Hondal - ACS chemical biology, 2016 - ACS Publications
The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases

A Bhattacharyya, R Chattopadhyay… - Physiological …, 2014 - journals.physiology.org
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

[HTML][HTML] Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes

M Deponte - Biochimica et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Glutathione and glutathione reductase: a boon in disguise for plant abiotic stress defense operations

SS Gill, NA Anjum, M Hasanuzzaman, R Gill… - Plant Physiology and …, 2013 - Elsevier
Abiotic stresses such as salinity, drought, clilling, heavy metal are the major limiting factors
for crop productivity. These stresses induce the overproduction of reactive oxygen species …

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …

Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions

ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

Thioredoxin and glutaredoxin systems in plants: molecular mechanisms, crosstalks, and functional significance

Y Meyer, C Belin, V Delorme-Hinoux… - Antioxidants & redox …, 2012 - liebertpub.com
Abstract Thioredoxins (Trx) and glutaredoxins (Grx) constitute families of thiol
oxidoreductases. Our knowledge of Trx and Grx in plants has dramatically increased during …

Immunity-Related Genes and Gene Families in Anopheles gambiae

GK Christophides, E Zdobnov, C Barillas-Mury… - Science, 2002 - science.org
We have identified 242 Anopheles gambiae genes from 18 gene families implicated in
innate immunity and have detected marked diversification relative to Drosophila …

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

A Bindoli, MP Rigobello, G Scutari, C Gabbiani… - Coordination Chemistry …, 2009 - Elsevier
The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …