SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Animal models for COVID-19: advances, gaps and perspectives

C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - Signal transduction and …, 2022 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this
century. Since the outbreak in late 2019, animal models have been playing crucial roles in …

ACE2-independent alternative receptors for SARS-CoV-2

S Lim, M Zhang, TL Chang - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), the causative agent
of coronavirus disease 2019 (COVID-19), is highly contagious and remains a major public …

Mitochondrial DNA and TLR9 activation contribute to SARS-CoV-2-induced endothelial cell damage

TJ Costa, SR Potje, TFC Fraga-Silva… - Vascular …, 2022 - Elsevier
Background and purpose Mitochondria play a central role in the host response to viral
infection and immunity, being key to antiviral signaling and exacerbating inflammatory …

Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Experimental models of COVID-19

LA Caldera-Crespo, MJ Paidas, S Roy… - Frontiers in cellular …, 2022 - frontiersin.org
COVID-19 is the most consequential pandemic of the 21st century. Since the earliest stage
of the 2019-2020 epidemic, animal models have been useful in understanding the …

The role of dendritic cells in COVID-19 infection

X Wang, F Guan, H Miller, MG Byazrova… - Emerging Microbes & …, 2023 - Taylor & Francis
The persistent pandemic of coronavirus disease in 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a major infectious …

Molecular and biological mechanisms underlying gender differences in COVID-19 severity and mortality

Z Wehbe, SH Hammoud, HM Yassine… - Frontiers in …, 2021 - frontiersin.org
Globally, over two million people have perished due to the recent pandemic caused by
SARS-CoV-2. The available epidemiological global data for SARS-CoV-2 portrays a higher …

CAR T cells: engineered immune cells to treat brain cancers and beyond

Z Huang, S Dewanjee, P Chakraborty, NK Jha, A Dey… - Molecular cancer, 2023 - Springer
Malignant brain tumors rank among the most challenging type of malignancies to manage.
The current treatment protocol commonly entails surgery followed by radiotherapy and/or …

COVID-19: A redox disease—What a stress pandemic can teach us about resilience and what we may learn from the reactive species interactome about its treatment

AF Cumpstey, AD Clark, J Santolini… - Antioxidants & Redox …, 2021 - liebertpub.com
Significance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus
causing coronavirus disease 2019 (COVID-19), affects every aspect of human life by …