Tuberculosis drug discovery: challenges and new horizons

GFS Fernandes, AM Thompson… - Journal of Medicinal …, 2022 - ACS Publications
Over the past 2000 years, tuberculosis (TB) has claimed more lives than any other infectious
disease. In 2020 alone, TB was responsible for 1.5 million deaths worldwide, comparable to …

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

K Dheda, T Gumbo, G Maartens, KE Dooley… - The lancet Respiratory …, 2017 - thelancet.com
Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Drug resistant Tuberculosis: A review

JL Khawbung, D Nath, S Chakraborty - … immunology, microbiology and …, 2021 - Elsevier
Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming
counter attack of TB worldwide. However, when it was known that TB can be cured …

Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

M Merker, C Blin, S Mona, N Duforet-Frebourg… - Nature …, 2015 - nature.com
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are
associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia …

[HTML][HTML] New agents for the treatment of drug-resistant Mycobacterium tuberculosis

DT Hoagland, J Liu, RB Lee, RE Lee - Advanced drug delivery reviews, 2016 - Elsevier
Inadequate dosing and incomplete treatment regimens, coupled with the ability of the
tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have …

History of antimicrobial drug discovery: Major classes and health impact

R Aminov - Biochemical pharmacology, 2017 - Elsevier
The introduction of antibiotics into clinical practice revolutionized the treatment and
management of infectious diseases. Before the introduction of antibiotics, these diseases …

Global control of tuberculosis: from extensively drug-resistant to untreatable tuberculosis

K Dheda, T Gumbo, NR Gandhi, M Murray… - The lancet Respiratory …, 2014 - thelancet.com
Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

[HTML][HTML] Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

[HTML][HTML] Genomic insights into tuberculosis

JE Galagan - Nature Reviews Genetics, 2014 - nature.com
Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

Long-term outcomes of patients with extensively drug-resistant tuberculosis in South Africa: a cohort study

E Pietersen, E Ignatius, EM Streicher, B Mastrapa… - The Lancet, 2014 - thelancet.com
Background Long-term treatment-related outcomes in patients with extensively drug-
resistant (XDR) tuberculosis are unknown. We followed up a cohort of patients to address …