Hyperbaric oxygen: its mechanisms and efficacy

SR Thom - Plastic and reconstructive surgery, 2011 - journals.lww.com
Background: This article outlines therapeutic mechanisms of hyperbaric oxygen therapy and
reviews data on its efficacy for clinical problems seen by plastic and reconstructive …

Oxidative stress is fundamental to hyperbaric oxygen therapy

SR Thom - Journal of applied physiology, 2009 - journals.physiology.org
The goal of this review is to outline advances addressing the role that reactive species of
oxygen and nitrogen play in therapeutic mechanisms of hyperbaric oxygen. The review will …

Platelet-derived growth factor-AB limits the extent of myocardial infarction in a rat model: feasibility of restoring impaired angiogenic capacity in the aging heart

JM Edelberg, SH Lee, M Kaur, L Tang, NM Feirt… - Circulation, 2002 - Am Heart Assoc
Background—Compared with younger patients, myocardial infarction in the elderly has
been associated with less favorable clinical outcomes, which may be attributable to a …

Hypoxia in obesity and diabetes: potential therapeutic effects of hyperoxia and nitrate

R Norouzirad, P González-Muniesa… - … medicine and cellular …, 2017 - Wiley Online Library
The prevalence of obesity and diabetes is increasing worldwide. Obesity and diabetes are
associated with oxidative stress, inflammation, endothelial dysfunction, insulin resistance …

Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application

P Saxena, MAJ Newman, JS Shehatha… - Journal of cardiac …, 2010 - Wiley Online Library
Remote ischemic conditioning is a novel concept of protection against ischemia‐reperfusion
injury. Brief controlled episodes of intermittent ischemia of the arm or leg may confer a …

Cardiovascular effects of hyperoxia during and after cardiac surgery

AME Spoelstra‐de Man, B Smit… - …, 2015 - Wiley Online Library
During and after cardiac surgery with cardiopulmonary bypass, high concentrations of
oxygen are routinely administered, with the intention of preventing cellular hypoxia. We …

Hyperoxia may be beneficial

E Calzia, P Asfar, B Hauser, M Matejovic… - Critical care …, 2010 - journals.lww.com
The current practice of mechanical ventilation comprises the use of the least inspiratory O 2
fraction associated with an arterial O 2 tension of 55 to 80 mm Hg or an arterial hemoglobin …

Actin S-nitrosylation inhibits neutrophil β2 integrin function

SR Thom, VM Bhopale, DJ Mancini… - Journal of Biological …, 2008 - ASBMB
The focus of this work was to elucidate the mechanism for inhibition of neutrophil β 2 integrin
adhesion molecules by hyperoxia. Results demonstrate that exposure to high oxygen partial …

Hyperoxia during cardiopulmonary bypass does not decrease cardiovascular complications following cardiac surgery: the CARDIOX randomized clinical trial

O Abou-Arab, P Huette, L Martineau, C Beauvalot… - Intensive Care …, 2019 - Springer
Purpose Data on the benefit or or harmful effects of oxygen level on ischemic reperfusion
injuries in cardiac surgery are insufficient. We hypothesized that hyperoxia during …

Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase

G Li, F Labruto, A Sirsjö, F Chen… - European journal of …, 2004 - academic.oup.com
Objective: Adaptation to ischemia by brief episodes of ischemia and reperfusion
(preconditioning) of the heart protects the heart against sustained ischemia, where the …