Oligonucleotide gene therapy (OGT) agents (eg antisense, deoxyribozymes, siRNA and
CRISPR/Cas) are promising therapeutic tools. Despite extensive efforts, only few OGT drugs …

DNA has the ability to form polymorphic structures like canonical duplex DNA and non-
canonical triplex DNA, Cruciform, Z-DNA, G-quadruplex (G4), i-motifs, and hairpin structures …

Over 80% of multiple-tested siRNAs and shRNAs targeting CD95 or CD95 ligand (CD95L)
induce a form of cell death characterized by simultaneous activation of multiple cell death …

Gynecological malignancies are a significant cause of morbidity and mortality across the
globe. Due to delayed presentation, gynecological cancer patients are often referred late in …

Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative
diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene …

Blocking androgen receptor signaling is the mainstay of therapy for advanced prostate
cancer (PCa). However, acquired resistance to single agents targeting this pathway results …

Many small-interfering (si) RNAs are toxic to cancer cells through a 6mer seed sequence
(positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer …

Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women,
and development of resistance to platinum remains a major barrier to achieving a cure …

Ovarian cancer is one of the most common causes of mortality throughout the world.
Unfortunately, chemotherapy has failed to cure advanced cancers developing multidrug …

Abstract micro (mi) RNAs are short noncoding RNAs that through their seed sequence (pos.
2–7/8 of the guide strand) regulate cell function by targeting complementary sequences …