Indocyanine green (ICG) is a water-soluble dye that was approved by the FDA for
biomedical purposes in 1956. Initially used to measure cardiocirculatory and hepatic …

Significance This third biennial intraoperative molecular imaging (IMI) conference shows
how optical contrast agents have been applied to develop clinically significant endpoints …

The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging.
However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the …

Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and
high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and …

Purpose The surgery of glioblastoma (GBM) requires a maximal resection of the tumor when
it is safe and feasible. The infiltrating growth property of the GBM makes it a challenge for …

Background Surgery is crucial for glioma treatment, but achieving complete tumour removal
remains challenging. We evaluated the effectiveness of a probe targeting monocarboxylate …

Introduction Surgical resection remains the first-line treatment for gliomas. Several
fluorescent dyes are currently in use to augment intraoperative tumor visualization, but …

Significance ALA-PpIX and second-window indocyanine green (ICG) have been studied
widely for guiding the resection of high-grade gliomas. These agents have different …

This review provides a comprehensive overview of the therapeutic and diagnostic
implications of fluorescence imaging in neurosurgery. Fluorescence imaging has become a …

OBJECTIVE The highly infiltrative growth of glioblastoma (GBM) makes distinction between
the tumor and normal brain tissue challenging. Therefore, fluorescence-guided surgery is …