Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be
effective against a wide spectrum of diseases and conditions, including neurological …

Background Nicotinamide (NAM) is a form of vitamin B3 that, when administered at near-
gram doses, has been shown or suggested to be therapeutically effective against many …

Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either
PKD1 or PKD2 and is characterized by the development of multiple bilateral renal cysts that …

Neutrophils are the most abundant innate immune cells. Multiple mechanisms allow them to
engage a wide range of metabolic pathways for biosynthesis and bioenergetics for …

Neutrophils, the first immune cells infiltrating an implantation site, play a central role in the
immune response to biomaterial-based implants. They initiate inflammation by secreting pro …

The incidence of skin cancer has gradually increased in the last years and exposition to
ultraviolet radiation remains the main risk factor. We performed a comprehensive review on …

Trillions of microorganisms, termed the “microbiota”, reside in the mammalian
gastrointestinal tract, and collectively participate in regulating the host phenotype. It is now …

Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions
such as cyclobutane pyrimidine dimers and 8‐oxo‐7‐hydrodeoxyguanosine. The production …

Antioxidants are promising compounds with antimicrobial activity against drug-resistant
pathogens, especially when combined with conventional antimicrobials. Our study aimed to …

Nicorandil is a drug characterized by the coupling of a nitric oxide (NO) donor to
nicotinamide. We have previously demonstrated that nicotinamide exhibits activity in …