In chemical terms, the regio-and stereoselective hydroxylation of hydrocarbon CH bonds is a
very difficult transformation. Nevertheless, these reactions are deftly catalyzed by a variety of …

The introduction of oxygen into biochemical processes has brought about an evolutionary
leap in the history of life, whereby many organisms have evolved to use oxygen as part of …

Enzymes are complex biological catalysts and are critical to life. Most oxidations of
chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize …

A current challenge in synthetic organic chemistry is the development of methods that allow
the regio-and stereoselective oxidative C–H activation of natural or synthetic compounds …

Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …

Selective oxidation of saturated C–H bonds remains a challenge in modern chemistry. The
inert nature of such bonds requires the use of highly reactive reagents, and this poses major …

Metal− oxos are critical intermediates for the management of oxygen and its activation. The
reactivity of the metal− oxo is central to the formation of O− O bonds, which is the essential …

Iron (V)-oxo species have been proposed as key reactive intermediates in the catalysis of
oxygen-activating enzymes and synthetic catalysts. Here, we report the synthesis of [Fe …

Production of NO from arginine and molecular oxygen is a complex chemical reaction
unique to biology. Our understanding of the chemical and regulation mechanisms of the NO …

Recently, we reported the spectroscopic and kinetic characterizations of cytochrome P450
compound I in CYP119A1, effectively closing the catalytic cycle of cytochrome P450 …