Role of oligodendrocytes and myelin in the pathophysiology of autism spectrum disorder

AY Galvez-Contreras, D Zarate-Lopez… - Brain sciences, 2020 - mdpi.com
Autism Spectrum Disorder (ASD) is an early neurodevelopmental disorder that involves
deficits in interpersonal communication, social interaction, and repetitive behaviors …

Saturation genome editing of BAP1 functionally classifies somatic and germline variants

AJ Waters, T Brendler-Spaeth, D Smith, V Offord… - Nature Genetics, 2024 - nature.com
Many variants that we inherit from our parents or acquire de novo or somatically are rare,
limiting the precision with which we can associate them with disease. We performed …

L-type calcium channels and neuropsychiatric diseases: Insights into genetic risk variant-associated genomic regulation and impact on brain development

MR Baker, AS Lee, AM Rajadhyaksha - Channels, 2023 - Taylor & Francis
Recent human genetic studies have linked a variety of genetic variants in the CACNA1C
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …

SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system

M Malara, AK Lutz, B Incearap, HF Bauer… - Cellular and Molecular …, 2022 - Springer
Mutations or deletions of the SHANK3 gene are causative for Phelan–McDermid syndrome
(PMDS), a syndromic form of autism spectrum disorders (ASDs). We analyzed Shank3Δ11 …

Neonatal curcumin treatment restores hippocampal neurogenesis and improves autism-related behaviors in a mouse model of autism

H Zhong, R Xiao, R Ruan, H Liu, X Li, Y Cai, J Zhao… - …, 2020 - Springer
Abstract Rationale Autism spectrum disorders (ASDs) are highly prevalent
neurodevelopmental disorders characterized by deficits in social communication and …

[HTML][HTML] Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour

A Ratsika, MG Codagnone, TFS Bastiaanssen… - Brain, Behavior, and …, 2024 - Elsevier
The developing central nervous system is highly sensitive to nutrient changes during the
perinatal period, emphasising the potential impact of alterations of maternal diet on offspring …

A clinically relevant selective ERK-pathway inhibitor reverses core deficits in a mouse model of autism

K Murari, A Abushaibah, JM Rho, RW Turner… - …, 2023 - thelancet.com
Background Extracellular signal-regulated kinase (ERK/MAPK) pathway in the brain is
hypothesized to be a critical convergent node in the development of autism spectrum …

[HTML][HTML] Plant-mediated green synthesis of gold nanoparticles using an aqueous extract of Passiflora ligularis, optimization, characterizations, and their …

NS Al-Radadi, WM Al-Bishri, NA Salem… - Saudi Pharmaceutical …, 2024 - Elsevier
The current study was conducted to examine an innovative method for synthesizing gold
nanoparticles (AuNPs) from an aqueous sweet granadilla (Passiflora ligularis Juss) P …

Atypical visual processing in a mouse model of autism

N Cheng, E Pagtalunan, A Abushaibah, J Naidu… - Scientific reports, 2020 - nature.com
Human social cognition relies heavily on the processing of various visual cues, such as eye
contact and facial expressions. Atypical visual perception and integration have been …

[HTML][HTML] A ketogenic diet affects brain volume and metabolome in juvenile mice

S Mayengbam, J Ellegood, M Kesler, RA Reimer… - Neuroimage, 2021 - Elsevier
Ketogenic diet (KD) is a high-fat and low-carbohydrate therapy for medically intractable
epilepsy, and its applications in other neurological conditions, including those occurring in …