Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies

S Xu, I Ilyas, J Weng - Acta Pharmacologica Sinica, 2023 - nature.com
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …

The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2

L Bauer, BM Laksono, FMS de Vrij, SA Kushner… - Trends in …, 2022 - cell.com
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is associated with
a diverse spectrum of neurological complications during the acute and postacute stages …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of …

E Avolio, M Carrabba, R Milligan… - Clinical …, 2021 - portlandpress.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a broad range
of clinical responses including prominent microvascular damage. The capacity of SARS …

COVID-19 and the vasculature: current aspects and long-term consequences

B Martinez-Salazar, M Holwerda, C Stuedle… - Frontiers in cell and …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was first identified in
December 2019 as a novel respiratory pathogen and is the causative agent of Corona Virus …

Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early-and late-phase COVID-19

J Radke, J Meinhardt, T Aschman, RL Chua… - Nature …, 2024 - nature.com
Neurological symptoms, including cognitive impairment and fatigue, can occur in both the
acute infection phase of coronavirus disease 2019 (COVID-19) and at later stages, yet the …

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19

E Kawakami, N Saiki, Y Yoneyama, C Moriya… - Cell Stem Cell, 2023 - cell.com
COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …

Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19

C Matsumoto, S Shibata, T Kishi, S Morimoto… - Hypertension …, 2023 - nature.com
Abstracts The coronavirus disease 2019 (COVID-19) affects infected patients even after the
acute phase and impairs their health and quality of life by causing a wide variety of …