The molecular processes underlying human health and disease are highly complex. Often,
genetic and environmental factors contribute to a given disease or phenotype in a non …

The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that
follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or …

Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring
diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The …

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

Infection with SARS-CoV-2 results in clinical outcomes ranging from silent or benign
infection in most individuals to critical pneumonia and death in a few. Genetic studies in …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Disclosures: C. Flores reported grants from Instituto de Salud Carlos III, Spanish Ministry of
Science and Innovation, and Cabildo Insular de Tenerife outside the submitted work. J …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19
pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients …