Directed evolution: methodologies and applications
Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …
and systems in a test tube through iterative rounds of gene diversifications and library …
Single-cell metabolomics: analytical and biological perspectives
R Zenobi - Science, 2013 - science.org
Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …
Biosensor technology: recent advances in threat agent detection and medicine
Biosensors are of great significance because of their capability to resolve a potentially large
number of analytical problems and challenges in very diverse areas such as defense …
number of analytical problems and challenges in very diverse areas such as defense …
Single‐Cell Mass Spectrometry for Discovery Proteomics: Quantifying Translational Cell Heterogeneity in the 16‐Cell Frog (Xenopus) Embryo
C Lombard‐Banek, SA Moody… - Angewandte Chemie, 2016 - Wiley Online Library
We advance mass spectrometry from a cell population‐averaging tool to one capable of
quantifying the expression of diverse proteins in single embryonic cells. Our instrument …
quantifying the expression of diverse proteins in single embryonic cells. Our instrument …
The single-probe: a miniaturized multifunctional device for single cell mass spectrometry analysis
N Pan, W Rao, NR Kothapalli, R Liu… - Analytical …, 2014 - ACS Publications
We have developed a new mass spectrometry (MS) technology, the Single-probe MS,
capable of real-time, in situ metabolomic analysis of individual living cells. The Single-probe …
capable of real-time, in situ metabolomic analysis of individual living cells. The Single-probe …
Categorizing cells on the basis of their chemical profiles: progress in single-cell mass spectrometry
The chemical differences between individual cells within large cellular populations provide
unique information on organisms' homeostasis and the development of diseased states …
unique information on organisms' homeostasis and the development of diseased states …
Single-cell mass spectrometry reveals small molecules that affect cell fates in the 16-cell embryo
Spatial and temporal changes in molecular expression are essential to embryonic
development, and their characterization is critical to understand mechanisms by which cells …
development, and their characterization is critical to understand mechanisms by which cells …
Deciphering metabolic heterogeneity by single-cell analysis
Single-cell analysis provides insights into cellular heterogeneity and dynamics of individual
cells. This Feature highlights recent developments in key analytical techniques suited for …
cells. This Feature highlights recent developments in key analytical techniques suited for …
Ultrasensitive single cell metabolomics by capillary electrophoresis–mass spectrometry with a thin-walled tapered emitter and large-volume dual sample …
T Kawai, N Ota, K Okada, A Imasato, Y Owa… - Analytical …, 2019 - ACS Publications
Single cell metabolome analysis is essential for studying microscale life phenomena such
as neuronal networks and tumor microenvironments. Capillary electrophoresis–mass …
as neuronal networks and tumor microenvironments. Capillary electrophoresis–mass …
In vivo subcellular mass spectrometry enables proteo‐metabolomic single‐cell systems biology in a chordate embryo developing to a normally behaving tadpole (X …
C Lombard‐Banek, J Li, EP Portero… - Angewandte …, 2021 - Wiley Online Library
We report the development of in vivo subcellular high‐resolution mass spectrometry (HRMS)
for proteo‐metabolomic molecular systems biology in complex tissues. With light …
for proteo‐metabolomic molecular systems biology in complex tissues. With light …