In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …

To model human neural-cell-fate specification and to provide cells for regenerative
therapies, we have developed a method to generate human neural progenitors and neurons …

Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …

The study of human cortical development has major implications for brain evolution and
diseases but has remained elusive due to paucity of experimental models. Here we found …

Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models,
whether and how grafts functionally repair damaged neural circuitry in the adult brain is not …

Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant
progress in recent years. However, most differentiated populations exhibit immature …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Monogenic neurodevelopmental disorders provide key insights into the pathogenesis of
disease and help us understand how specific genes control the development of the human …

Human pluripotent stem cells (hPSCs) have been differentiated efficiently to neuronal cell
types. However, directed differentiation of hPSCs to astrocytes and astroglial subtypes …