Host genetic determinants of hepatitis B virus infection

Z Zhang, C Wang, Z Liu, G Zou, J Li, M Lu - Frontiers in genetics, 2019 - frontiersin.org
Chronic hepatitis B virus (HBV) infection is still a major health problem worldwide. Recently,
a great number of genetic studies based on single nucleotide polymorphisms (SNPs) and …

A review of HLA allele and SNP associations with highly prevalent infectious diseases in human populations

A Sanchez-Mazas - Swiss medical weekly, 2020 - smw.ch
Human leucocyte antigen (HLA) alleles and single nucleotide polymorphisms (SNPs) lying
in the HLA region are known to be associated with several infectious diseases among which …

The hepatitis B virus-associated tumor microenvironment in hepatocellular carcinoma

P Yang, GJ Markowitz, XF Wang - National science review, 2014 - academic.oup.com
In contrast to a majority of cancer types, the initiation of hepatocellular carcinoma (HCC) is
intimately associated with a chronically diseased liver tissue, with one of the most prevalent …

[HTML][HTML] Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

IM Akcay, S Katrinli, K Ozdil, GD Doganay… - World journal of …, 2018 - ncbi.nlm.nih.gov
The clinical outcome of hepatitis B virus (HBV) infection depends on the success or failure of
the immune responses to HBV, and varies widely among individuals, ranging from …

Human leukocyte antigen (HLA) system: genetics and association with bacterial and viral infections

S Medhasi, N Chantratita - Journal of Immunology Research, 2022 - Wiley Online Library
The human leukocyte antigen (HLA) system is one of the most crucial host factors
influencing disease progression in bacterial and viral infections. This review provides the …

Clinical relevance of HLA gene variants in HBV infection

L Wang, ZQ Zou, K Wang - Journal of immunology research, 2016 - Wiley Online Library
Host gene variants may influence the natural history of hepatitis B virus (HBV) infection. The
human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in …

Hepatitis B virus molecular epidemiology, host-virus interaction, coinfection, and laboratory diagnosis in the MENA region: An update

DW Al-Sadeq, SA Taleb, RE Zaied, SM Fahad… - Pathogens, 2019 - mdpi.com
Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause
acute and chronic hepatitis. According to the World Health Organization (WHO) and the …

A genome-wide association study on chronic HBV infection and its clinical progression in male Han-Taiwanese

SW Chang, CSJ Fann, WH Su, YC Wang, CC Weng… - PloS one, 2014 - journals.plos.org
It is common to observe the clustering of chronic hepatitis B surface antigen (HBsAg) carriers
in families. Intra-familial transmission of hepatitis B virus (HBV) could be the reason for the …

Genetic factors that affect spontaneous clearance of hepatitis C or B virus, response to treatment, and disease progression

TR O'Brien, HI Yang, S Groover, WJ Jeng - Gastroenterology, 2019 - Elsevier
Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections can lead to cirrhosis, end-
stage liver disease, and hepatocellular carcinoma. Over the past decade, studies of …

Understanding of HLA-conferred susceptibility to chronic hepatitis B infection requires HLA genotyping-based association analysis

N Nishida, J Ohashi, SS Khor, M Sugiyama… - Scientific reports, 2016 - nature.com
Associations of variants located in the HLA class II region with chronic hepatitis B (CHB)
infection have been identified in Asian populations. Here, HLA imputation method was …