Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …

Extracellular vesicles (EVs) are a heterogeneous group of membrane-limited vesicles and
multi-signal messengers loaded with biomolecules. Exosomes and ectosomes are two …

Extracellular vesicles (EVs) mediate cell-to-cell communication via the transfer of
biomolecules locally and systemically between organs. It has been elucidated that the …

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, affecting
1–1.5% of the total population. While progress has been made in understanding the …

Endosomal recycling of transmembrane proteins requires sequence-dependent recognition
of motifs present within their intracellular cytosolic domains. In this study, we have …

The endosomal sorting complex required for transport (ESCRT) machinery is composed of
five multi-subunit protein complexes, which act cooperatively at specialized endosomes to …

Endosomes are major protein sorting stations in cells. Endosomally localised multi-protein
complexes sort integral proteins, including signaling receptors, nutrient transporters …

The ESCRT machinery is an ancient, evolutionarily conserved membrane remodelling
complex that is deployed by cells to perform a diverse collection of physiological and …

Highlights•Actin polymerization on endosomes is primarily controlled by the regulation of the
WASH complex activity.•Endosomal actin restricts the lateral mobility of cargoes and …