Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to
different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis …

Dysregulated metabolism is an emerging hallmark of cancer, and there is abundant interest
in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at …

Adult stem cells, particularly those resident in tissues with little turnover, are largely
quiescent and only activate in response to regenerative demands, while embryonic stem …

Pluripotent stem cells (PSCs), including embryonic stem cells (ESCs) and induced
pluripotent stem cells (iPSCs), hold a huge promise for regenerative medicine, drug …

Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells
by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a …

The ability to shift between metabolic states and to tightly regulate cellular mechanical
properties have been described as crucial events in the achievement of correct embryonic …

Amino acids are crucial nutrients involved in several cellular and physiological processes,
including fertilization and early embryo development. In particular, Leucine and Arginine …

Pluripotent stem cells of the mammalian epiblast and their cultured counterparts—embryonic
stem cells (ESCs) and epiblast stem cells (EpiSCs)—have the capacity to differentiate in all …

Background Pluripotent stem cells promise innovative approaches for enduring diseases,
including disease modeling and drug screens. Accordingly, efforts have been undertaken in …