[HTML][HTML] Design of experiments (DoE) applied to pharmaceutical and analytical quality by design (QbD)

IM Fukuda, CFF Pinto, CS Moreira… - Brazilian journal of …, 2018 - SciELO Brasil
According to Quality by Design (QbD) concept, quality should be built into product/method
during pharmaceutical/analytical development. Usually, there are many input factors that …

Progress in nasal drug delivery systems

F Laffleur, B Bauer - International Journal of Pharmaceutics, 2021 - Elsevier
Most of the available drugs are usually administered orally (eg in tablets or capsules) or by
parenteral injection in the case of substances being destroyed in the gastric environment or …

Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications

HF Darge, AT Andrgie, HC Tsai, JY Lai - International journal of biological …, 2019 - Elsevier
Injectable thermo-responsive hydrogels have been studied for various biomedical
applications including; drug delivery, cell encapsulation, and tissue repairing. There are …

[图书][B] Natural polysaccharides in drug delivery and biomedical applications

MS Hasnain, AK Nayak - 2019 - books.google.com
Natural Polysaccharides in Drug Delivery and Biomedical Applications provides a
fundamental overview of natural polysaccharides, their sources, extraction methodologies …

Nose-to-brain delivery of teriflunomide-loaded lipid-based carbopol-gellan gum nanogel for glioma: Pharmacological and in vitro cytotoxicity studies

D Gadhave, N Rasal, R Sonawane, M Sekar… - International Journal of …, 2021 - Elsevier
The research work was intended to formulate teriflunomide (TFM) loaded nano lipid-based
(TNLC) carbopol-gellan gum in situ gel (TNLCGHG) and to investigate its therapeutic …

Microemulsion-based media in nose-to-brain drug delivery

A Froelich, T Osmałek, B Jadach, V Puri… - Pharmaceutics, 2021 - mdpi.com
Nose-to-brain drug delivery has recently attracted enormous attention as an alternative to
other delivery routes, including the most popular oral one. Due to the unique anatomical …

Application of design of experiments (DoE) in pharmaceutical product and process optimization

S Beg, S Swain, M Rahman, MS Hasnain… - Pharmaceutical quality by …, 2019 - Elsevier
The development of pharmaceutical drug products involves a multitude of functional and
nonfunctional excipients, a series of processes, and manufacturing steps. Hence, the …

In vitro evaluation of nasal aerosol depositions: an insight for direct nose to brain drug delivery

A Maaz, IS Blagbrough, PA De Bank - Pharmaceutics, 2021 - mdpi.com
The nasal cavity is an attractive route for both local and systemic drug delivery and holds
great potential for access to the brain via the olfactory region, an area where the blood–brain …

Nanotechnologies for intranasal drug delivery: an update of literature

R Lombardo, T Musumeci, C Carbone… - Pharmaceutical …, 2021 - Taylor & Francis
Scientific research has focused its attention on finding an alternative route to systemic oral
and parenteral administration, to overcome their usual drawbacks, such as hepatic first-pass …

[HTML][HTML] Nanotechnological advances for nose to brain delivery of therapeutics to improve the Parkinson therapy

DK Khatri, K Preeti, S Tonape… - Current …, 2023 - ncbi.nlm.nih.gov
Abstract Blood-Brain Barrier (BBB) acts as a highly impermeable barrier, presenting an
impediment to the crossing of most classical drugs targeted for neurodegenerative diseases …