Lung cancer is the leading cause of cancer deaths worldwide, and this makes it an attractive
disease to review and possibly improve therapeutic treatment options. Surgery, radiation …

Inflammation in the tumor microenvironment is a hallmark of cancer and is recognized as a
key characteristic of carcinogens. However, the failure of resolution of inflammation in …

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at
risk for malignant transformation. However, accumulating evidence shows that senescent …

An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole,
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …

Angiogenesis is required for invasive tumor growth and metastasis and constitutes an
important point in the control of cancer progression. Its inhibition may be a valuable new …

Radiotherapy is generally used to treat a localised target that includes cancer. Increasingly,
evidence indicates that radiotherapy recruits biological effectors outside the treatment field …

Metastases account for most cancer-related deaths, yet the mechanisms underlying
metastatic spread remain poorly understood. Recent evidence demonstrates that senescent …

Cellular senescence, which is associated with aging, is a process by which cells enter a
state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive …

Angiogenesis inhibitors are a new class of drugs, for which the general rules involving
conventional chemotherapy might not apply. The successful translation of angiogenesis …

The process of angiogenesis encompasses the growth and regression of capillary blood
vessels. Angiogenesis is finely regulated at the molecular and genetic levels, not unlike …