The lungs were long thought to be sterile until technical advances uncovered the presence
of the lung microbial community. The microbiome of healthy lungs is mainly derived from the …

The immune system is tasked with identifying malignant cells to eliminate or prevent cancer
spread. This involves a complex orchestration of many immune cell types that together …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic
with millions of human infections. One limitation to the evaluation of potential therapies and …

The microbiota is known to modulate the host response to influenza infection through as-yet-
unclear mechanisms. We hypothesized that components of the microbiota exert effects …

In the mammalian intestine, crypts of Leiberkühn house intestinal epithelial stem/progenitor
cells at their base. The mammalian intestine also harbors a diverse array of microbial …

The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced
immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein …

Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic
mutations together with environmental triggers can disable Paneth cell function. Here, we …

Skin wounds heal by coordinated induction of inflammation and tissue repair, but the
initiating events are poorly defined. Here we uncover a fundamental role of commensal skin …

Adaptive cellular responses are often required during wound repair. Following disruption of
the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier …

BACKGROUND Viruses that infect the mammalian gastrointestinal tract have intimate
relationships with the host, as well as members of the complex community of microbes that …