HLA-G: an immune checkpoint molecule

ED Carosella, N Rouas-Freiss, D Tronik-Le Roux… - Advances in …, 2015 - Elsevier
HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Steroids, pregnancy and fetal development

ME Solano, PC Arck - Frontiers in immunology, 2020 - frontiersin.org
Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of
mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone …

Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions

DW Greening, HPT Nguyen, K Elgass… - Biology of …, 2016 - academic.oup.com
Embryo implantation into receptive endometrium requires synergistic endometrial-blastocyst
interactions within the uterine cavity and is essential for establishing pregnancy. We …

Galectin-1: a jack-of-all-trades in the resolution of acute and chronic inflammation

V Sundblad, LG Morosi, JR Geffner… - The Journal of …, 2017 - journals.aai.org
Regulatory signals provide negative input to immunological networks promoting resolution
of acute and chronic inflammation. Galectin-1 (Gal-1), a member of a family of evolutionarily …

Galectin-1: a traditionally immunosuppressive protein displays context-dependent capacities

X Yu, J Qian, L Ding, S Yin, L Zhou… - International Journal of …, 2023 - mdpi.com
Galectin–Carbohydrate interactions are indispensable to pathogen recognition and immune
response. Galectin-1, a ubiquitously expressed 14-kDa protein with an evolutionarily …

Tissue-and cell-specific localization of galectins, β-galactose-binding animal lectins, and their potential functions in health and disease

J Nio-Kobayashi - Anatomical science international, 2017 - Springer
Fifteen galectins, β-galactose-binding animal lectins, are known to be distributed throughout
the body. We herein summarize current knowledge on the tissue-and cell-specific …

Novel biomolecules in the pathogenesis of gestational diabetes mellitus

M Ruszała, M Niebrzydowska, A Pilszyk… - International Journal of …, 2021 - mdpi.com
Gestational diabetes mellitus (GDM) is one of the most common metabolic diseases in
pregnant women. Its early diagnosis seems to have a significant impact on the developing …

The dual role of HLA‐G in cancer

N Rouas-Freiss, P Moreau, J LeMaoult… - Journal of …, 2014 - Wiley Online Library
We here review the current data on the role of HLA‐G in cancer based on recent findings of
an unexpected antitumor activity of HLA‐G in hematological malignancies. For the past …

Interfering with Gal-1–mediated angiogenesis contributes to the pathogenesis of preeclampsia

N Freitag, I Tirado-González… - Proceedings of the …, 2013 - National Acad Sciences
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of
hypertension and proteinuria in the second half of pregnancy (> 20 wk). PE is strongly …

Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency

N Freitag, I Tirado-Gonzalez, G Barrientos… - Cell Death & …, 2020 - nature.com
Fetal growth restriction (FGR) is the most common pregnancy complication in developed
countries. Pregnancies affected by FGR, frequently concur with complications and high risk …