Schizophrenia is a devastating psychiatric illness that affects approximately 1% of the world
population irrespective of ethnic, economical, or cultural boundaries: features that suggest …

More than two decades of research indicate that the peptide neurotensin (NT) and its
cognate receptors participate to a remarkable extent in the regulation of mammalian …

Neurotensin is a 13-amino acid peptide (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-
Leu) originally isolated from hypothalami (Carraway and Leeman, 1973) and later from …

This study investigated, using microdialysis in freely-moving rats, the role of serotonin (5-HT)
and 5-HT2 receptor subtypes in the enhancement of striatal dopamine (DA) release induced …

Electrical stimulation (ES) in the brain is becoming a new treatment option in patients with
treatment-resistant obsessive-compulsive disorder (OCD). A possible brain target might be …

The recent development of selective and highly potent nonpeptide antagonists for peptide
receptors has constituted a major breakthrough in the field of neuropeptide research …

Nitric oxide (NO), the diffusible gas formed by nitric oxide synthase (NOS) has been
implicated in the enhanced locomotor activity attributed mainly to increased dopamine …

The possibility that the neuropeptide neurotensin (NT) may function as an endogenous
antipsychotic compound was first hypothesized almost two decades ago. Since that time …

In this study, we use in vivo microdialysis to investigate the influence of endogenous
serotonin (5-HT) on striatal dopamine (DA) and 5-hydroxyidoleacetic acid (5-HIAA) efflux in …

Abstract SSR181507 ((3-exo)-8-benzoyl-N-[[(2S) 7-chloro-2, 3-dihydro-1, 4-benzodioxin-1-
yl] methyl]-8-azabicyclo [3.2. 1] octane-3-methanamine monohydrochloride) is a novel …