Hormonal therapy for gynecological cancers: how far has science progressed toward clinical applications?

S Mitra, MS Lami, A Ghosh, R Das, TE Tallei… - Cancers, 2022 - mdpi.com
Simple Summary The most common therapies for severe and recurrent gynecological
cancers are hormone therapy and chemotherapy, and responsiveness to therapy is a key …

Plant-Derived Extracellular Vesicles as a Promising Anti-Tumor Approach: A Comprehensive Assessment of Effectiveness, Safety, and Mechanisms

W Qiang, J Li, R Ruan, Q Li, X Zhang, A Yan, H Zhu - Phytomedicine, 2024 - Elsevier
Background Plant-derived extracellular vesicles (PDEs) are expected to be a compelling
alternative for cancer treatment due to their low cytotoxicity, low immunogenicity, high yield …

Gaining insights into the compositional constraints and molecular phylogeny of five silkworms mitochondrial genome

R Abdoli, TH Mazumder, S Nematollahian… - International Journal of …, 2022 - Elsevier
This study was performed to identify codon usage bias (CUB), genetic similarity and
phylogenetic analysis of complete mitochondrial genomes along with separate sequences …

Relative synonymous codon usage and codon pair analysis of depression associated genes

R Khandia, P Gurjar, MA Kamal, NH Greig - Scientific Reports, 2024 - nature.com
Depression negatively impacts mood, behavior, and mental and physical health. It is the
third leading cause of suicides worldwide and leads to decreased quality of life. We …

Strong selectional forces fine-tune CpG content in genes involved in neurological disorders as revealed by codon usage patterns

R Khandia, A Sharma, T Alqahtani… - Frontiers in …, 2022 - frontiersin.org
Neurodegenerative disorders cause irreversible damage to the neurons and adversely
affect the quality of life. Protein misfolding and their aggregation in specific parts of the brain …

[HTML][HTML] Genes common in primary immunodeficiencies and cancer display overrepresentation of codon CTG and dominant role of selection pressure in shaping …

R Khandia, T Alqahtani, AM Alqahtani - Biomedicines, 2021 - mdpi.com
Primary immunodeficiencies (PIDs) are disorders of the immune system that involve faulty
cellular, humoral, or both cellular and humoral functions. PIDs are present at the crossroad …

[HTML][HTML] Leucine encoding codon TTG shows an inverse relationship with GC content in genes involved in neurodegeneration with iron accumulation

T Alqahtani, R Khandia, N Puranik… - Journal of Integrative …, 2021 - imrpress.com
We determined various forces involved in shaping codon usage of the genes linked to brain
iron accumulation and infantile neuroaxonal dystrophy. The analysis paved the way for …

Structural Characteristics and Phylogenetic Analysis of the Mitochondrial Genomes of Four Krisna Species (Hemiptera: Cicadellidae: Iassinae)

Y Yang, J Wang, R Dai, X Wang - Genes, 2023 - mdpi.com
Krisna species are insects that have piercing–sucking mouthparts and belong to the Krisnini
tribe in the Iassinae subfamily of leafhoppers in the Cicadellidae family. In this study, we …

Molecular Dissection of Herpes Simplex Virus Type 1 to Elucidate Molecular Mechanisms Behind Latency and Comparison of Its Codon Usage Patterns with Genes …

P Gurjar, AA Khan, AM Alanazi… - Journal of …, 2024 - content.iospress.com
Background: Herpes simplex virus type 1 (HSV-1) is associated with Alzheimer's disease,
which goes into a cycle of latency and reactivation. The present study was envisaged to …

An investigation of codon usage pattern analysis in pancreatitis associated genes

Y Li, R Khandia, M Papadakis, A Alexiou… - BMC Genomic …, 2022 - Springer
Background Pancreatitis is an inflammatory disorder resulting from the autoactivation of
trypsinogen in the pancreas. The genetic basis of the disease is an old phenomenon, and …