Historically, the main barrier to membrane protein investigations has been the tendency of
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …

Elevated blood/tissue glucose is a hallmark feature of advanced diabetes, and people with
diabetes are prone to more frequent and invasive infections with Staphylococcus aureus …

Targeting of extracellular protein–protein interactions (PPI) is emerging as a major
application for de novo discovered macrocyclic peptides. Modern discovery platforms can …

In Staphylococcus aureus, virulence is under the control of a quorum sensing (QS) circuit
encoded in the accessory gene regulator (agr) genomic locus. Key to this pathogenic …

We combined mRNA display technology with lipid-nanodisc based selections and identified
high-affinity ligands targeting the integral membrane sensor domain of the histidine kinase …

Staphylococcus aureus is a leading cause of hospital-acquired infections worldwide, and
cases of community-acquired infections are becoming more prevalent. The production of …

The formation of biofilm by pathogenic bacteria is considered as one of the most powerful
mechanisms/modes of resistance against the action of several antibiotics. Biofilm is formed …

The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-
antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive …

Gram-positive bacteria process and release small peptides, or pheromones, that act as
signals for the induction of adaptive traits, including those involved in pathogenesis. One …

Over millions of years, changes have occurred in regulatory circuitries in response to
genome reorganization and/or persistent changes in environmental conditions. How …