The keratins are the typical intermediate filament proteins of epithelia, showing an
outstanding degree of molecular diversity. Heteropolymeric filaments are formed by pairing …

Keratins, the major structural protein of all epithelia are a diverse group of cytoskeletal
scaffolding proteins that form intermediate filament networks, providing structural support to …

Intermediate filaments (IFs) are encoded by the largest gene family among the three major
cytoskeletal protein groups. Unique IF compliments are expressed in selective cell types …

The human keratin family comprises 54 members, 28 type I and 26 type II. Out of the 28 type
I keratins, 17 are epithelial and 11 are hair keratins. Similarly, the 26 type II members …

The term 'keratin'is generally accepted to refer to the epithelial keratins of soft and hard
epithelial tissues such as: skin, cornea, hair and nail. Since their initial characterization, the …

The mammalian hair follicle (HF) is a complex structure composed of several distinct cell
layers. The HF is an ectodermal appendage that resides in the skin, and unlike other tissues …

Mouse models have greatly helped in elucidating the molecular mechanisms involved in
hair formation and regeneration. Recent publications have reviewed the genes involved in …

Keratins are cytoskeletal proteins that provide structural support to epithelial cells and
tissues. Perturbation causes cell and tissue fragility and accounts for a large number of …

Pure hair and nail ectodermal dysplasia (PHNED) is a congenital condition characterized by
hypotrichosis and nail dystrophy. Autosomal-recessive PHNED has previously been …

Background Monilethrix is a rare hereditary hair disorder that is characterized by a beaded
hair shaft structure and increased hair fragility. Patients may also present with keratosis …