Keeping in view the involvement of inflammation in the pathogenesis of several diseases
including cancer, diabetes, neurodegenerative disorders and rheumatoid arthritis, herein …

Here we have outlined the recent (2011–2022) developments in the synthesis of modified
indomethacin-based analogues for the selective inhibition of COX-2 and then highlighted …

A new series of bis-triazole 19a-l was synthesised for the purpose of being hybrid molecules
with both anti-inflammatory and anti-cancer activities and assessed for cell cycle arrest, NO …

Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …

Abstract Selective cyclooxygenase-2 (COX-2) inhibitors have exhibited notable medicinal
importance. In recent years, the discovery of new anti-inflammatory agents as selective COX …

Abstract Cyclooxygenase-2 (COX-2), a key enzyme in the cyclooxygenase family, is pivotal
in producing pro-inflammatory prostaglandins, driving chronic inflammation and related …

Herein we report the design, synthesis, computational, and experimental evaluation of the
antimicrobial activity of fourteen new 3-amino-5-(indol-3-yl) methylene-4-oxo-2 …

New ibuprofen derivatives containing variously substituted pyrazoline have been
synthesized, characterized by FT-IR and 1H-NMR spectroscopy and evaluated preliminarily …

Background: A dual COX/5-LOX strategy was adopted to develop new oxindole derivatives
with superior anti-inflammatory activity. Methods: Three series of oxindoles–esters 4a–p, 6a …

Background: Dual COX/5-LOX inhibition is a bright strategy for developing new potent and
safe anti-inflammatory agents. Methods: New imines were synthesized and evaluated for …