Angiogenesis—the process of new blood-vessel growth—has an essential role in
development, reproduction and repair. However, pathological angiogenesis occurs not only …

Angiogenesis inhibitors for the treatment of cancer have now been approved by the Food
and Drug Administration in the United States, and in 28 other countries including China …

The first angiogenesis inhibitors for cancer have now been approved by the FDA in the US
and in 28 other countries, including China. The majority of these are monotherapies that …

Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have
been reported in various pathological conditions including cancer. Preclinical studies have …

Background Observations of adverse developmental and reproductive effects in laboratory
animals and wildlife have fueled increasing public concern regarding the potential for …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

Within three decades, anti-angiogenic therapy has rapidly evolved into an integral
component of current standard anti-cancer treatment. Anti-angiogenic therapy has fulfilled a …

Evidence is presented which supports the conclusion that the hormetic dose–response
model is the most common and fundamental in the biological and biomedical sciences …

Numerous extracellular proteins and glycosaminoglycans (GAG s) undergo limited
enzymatic cleavage resulting in the release of fragments exerting biological activities, which …

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from
Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20 (S)-ginsenoside Rg3 …