Coenzyme A biosynthesis: an antimicrobial drug target

C Spry, K Kirk, KJ Saliba - FEMS microbiology reviews, 2008 - academic.oup.com
Pantothenic acid, a precursor of coenzyme A (CoA), is essential for the growth of pathogenic
microorganisms. Since the structure of pantothenic acid was determined, many analogues of …

Enamide derivatives: versatile building blocks for total synthesis

T Courant, G Dagousset, G Masson - Synthesis, 2015 - thieme-connect.com
Enamides and enecarbamates are versatile building blocks in organic synthesis. This
review describes the development of enamide chemistry and the utility of the resulting …

Direct synthesis of enamides via electrophilic activation of amides

P Spieß, M Berger, D Kaiser… - Journal of the American …, 2021 - ACS Publications
A novel, one-step N-dehydrogenation of amides to enamides is reported. This reaction
employs the unlikely combination of LiHMDS and triflic anhydride, which serves as both the …

Enamides: valuable organic substrates

DR Carbery - Organic & Biomolecular Chemistry, 2008 - pubs.rsc.org
Enamides display a fine balance of stability and reactivity, which is now leading to their
increasing use in organic synthesis. Enamides offer multiple opportunities for the inclusion …

Solvent-Controlled, Atom-Economic, and Highly Regio-and Stereoselective Halo-Chalcogenations of Ynamides: Green Synthesis of Stereodefined Tetrasubstituted …

ANV Satyanarayana, P Pattanayak… - The Journal of Organic …, 2024 - ACS Publications
The synthesis of stereodefined tetrasubstituted alkenes bearing four different functional
groups is challenging. Herein, we disclose a 100% atom-economic and highly regio-and …

Recent Advances in Cobalt‐Catalyzed, Directing‐Group‐Assisted C− H Bond Amidation Reactions

S Sunny, R Karvembu - Advanced Synthesis & Catalysis, 2021 - Wiley Online Library
C− N bond formation reactions have garnered a lot of interest in recent years due to the
predominance of nitrogen‐containing compounds in most pharmacological medications …

Cp* Co (iii)-catalyzed amidation of olefinic and aryl C–H bonds: highly selective synthesis of enamides and pyrimidones

Y Liu, F Xie, AQ Jia, X Li - Chemical Communications, 2018 - pubs.rsc.org
A highly efficient and selective synthesis of enamides via C–H amidation of N-methoxy
acrylamides with dioxazolones is realized under [Cp* CoIII] catalysis. The resulting enamide …

Photoredox/Nickel dual-catalyzed stereoselective synthesis of distal cyano-substituted enamides

XY Lu, JC Wang, XM Sun, MT Gao… - The Journal of …, 2022 - ACS Publications
Herein, the efficient photoredox/nickel dual-catalyzed cyanoalkylation reaction of enamides
is illustrated. A wide scope of enamides and cycloketone oxime esters was well-tolerated …

Stereoselective synthesis of highly substituted enamides by an oxidative Heck reaction

Y Liu, D Li, CM Park - Angewandte Chemie, 2011 - infona.pl
Die Funktionalisierung von Enamiden unter Heck‐Bedingungen war bisher auf Enamide mit
unsubstituierten Vinylgruppen beschränkt. Durch Einstellen der Reaktionsparameter gelang …

n‐Bu4NI/K2S2O8 Mediated Csp2−Csp2 Bond Cleavage – Transformylation from p‐Anisaldehyde to Primary Amides

X Liu, S Hee, NG Sapir, A Li, J Liu… - Advanced Synthesis & …, 2024 - Wiley Online Library
Abstract n‐Bu4NI/K2S2O8 mediated transformylation from p‐anisaldehyde to primary
amides is reported. The mechanistic studies suggest the reaction occurs via a single …