Universality of critical active site glutamate as an acid–base catalyst in serine hydroxymethyltransferase function

VN Drago, RS Phillips, A Kovalevsky - Chemical Science, 2024 - pubs.rsc.org
Serine hydroxymethyltransferase (SHMT) is a key enzyme in the one-carbon metabolic
pathway, utilizing the vitamin B6 derivative pyridoxal 5′-phosphate (PLP) and vitamin B9 …

Counter-diffusion studies of human transthyretin: the growth of high-quality crystals for X-ray and neutron crystallography

C De'Ath, MF Oliva, M Moulin, MP Blakeley… - Applied …, 2025 - journals.iucr.org
A crystallogenesis study of human transthyretin using the counter-diffusion method is
described as an alternative to conventional convective vapour diffusion and batch …

[HTML][HTML] Monoclonal Antibodies from Space: Improved Crystallization Under Microgravity During Manufacturing in Orbit

S Amselem, D Kogan, O Loboda… - Journal of …, 2024 - xiahepublishing.com
This article explores the significant improvements in manufacturing of monoclonal
antibodies (mAbs) and antibody-drug conjugates (ADCs) enabled by the microgravity …