Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from Mycobacterium tuberculosis
The enhanced intracellular survival (Eis) protein of Mycobacterium tuberculosis (Mtb) is a
versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their …
versatile acetyltransferase that multiacetylates aminoglycoside antibiotics abolishing their …
An outline of the latest crystallographic studies on inhibitor-enzyme complexes for the design and development of new therapeutics against tuberculosis
M Mori, S Villa, S Ciceri, D Colombo, P Ferraboschi… - Molecules, 2021 - mdpi.com
The elucidation of the structure of enzymes and their complexes with ligands continues to
provide invaluable insights for the development of drugs against many diseases, including …
provide invaluable insights for the development of drugs against many diseases, including …
Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a deadly bacterial
disease. Drug-resistant strains of Mtb make eradication of TB a daunting task …
disease. Drug-resistant strains of Mtb make eradication of TB a daunting task …
Discovery and mechanistic analysis of structurally diverse inhibitors of acetyltransferase Eis among FDA-approved drugs
Over one and a half million people die of tuberculosis (TB) each year. Multidrug-resistant TB
infections are especially dangerous, and new drugs are needed to combat them. The high …
infections are especially dangerous, and new drugs are needed to combat them. The high …
Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as …
K Rocha, J Magallon, C Reeves, K Phan, P Vu… - Biomedicines, 2021 - mdpi.com
The aminoglycoside 6′-N-acetyltransferase type Ib (AAC (6′)-Ib) is a common cause of
resistance to amikacin and other aminoglycosides in Gram-negatives. Utilization of mixture …
resistance to amikacin and other aminoglycosides in Gram-negatives. Utilization of mixture …
N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in M. marinum
BS Jones, V Pareek, DD Hu, SD Weaver, C Syska… - bioRxiv, 2024 - biorxiv.org
Mycobacterial pathogens, including M. tuberculosis, the cause of human tuberculosis, and
the non-tubercular species, M. marinum lyse the host phagosome during infection …
the non-tubercular species, M. marinum lyse the host phagosome during infection …
Tuberculose: a importância da investigação de novos fármacos no contexto do desenvolvimento de estirpes de Mtb resistentes aos fármacos disponíveis
YS Buzan - 2022 - search.proquest.com
A tuberculose (TB) é uma doença bacteriana causada por Mycobacterium tuberculosis
(Mtb). Este agente infecioso é responsável por um grande número de infetados (1/3 da …
(Mtb). Este agente infecioso é responsável por um grande número de infetados (1/3 da …
[PDF][PDF] TESIS PARA OPTAR EL GRADO DE MAESTRO EN INFORMÁTICA BIOMÉDICA EN SALUD GLOBAL CON MENCIÓN EN BIOINFORMÁTICA MARIA …
MGS QUISPE - repositorio.upch.edu.pe
La tuberculosis (TB) es una enfermedad infecciosa causada por Mycobacterium
tuberculosis (1). Se encuentra entre las 10 principales causas de mortalidad en el mundo …
tuberculosis (1). Se encuentra entre las 10 principales causas de mortalidad en el mundo …