Gene–environment interaction: A variable selection perspective

F Zhou, J Ren, X Lu, S Ma, C Wu - Epistasis: Methods and Protocols, 2021 - Springer
Gene–environment interactions have important implications for elucidating the genetic basis
of complex diseases beyond the joint function of multiple genetic factors and their …

High-Dimensional Gene–Environment Interaction Analysis

M Wu, Y Li, S Ma - Annual Review of Statistics and Its …, 2024 - annualreviews.org
Beyond the main genetic and environmental effects, gene–environment (G–E) interactions
have been demonstrated to significantly contribute to the development and progression of …

Robust Bayesian Model Averaging for Linear Regression Models With Heavy-Tailed Errors

S De, J Ghosh - arXiv preprint arXiv:2407.16366, 2024 - arxiv.org
In this article, our goal is to develop a method for Bayesian model averaging in linear
regression models to accommodate heavier tailed error distributions than the normal …

Bayesian Approaches in Exploring Gene-environment and Gene-gene Interactions: A Comprehensive Review

NA Sun, YU Wang, J Chu, Q Han… - Cancer Genomics & …, 2023 - cgp.iiarjournals.org
Rapid advancements in high-throughput biological techniques have facilitated the
generation of high-dimensional omics datasets, which have provided a solid foundation for …

[HTML][HTML] Is Seeing Believing? A Practitioner's Perspective on High-Dimensional Statistical Inference in Cancer Genomics Studies

K Fan, S Subedi, G Yang, X Lu, J Ren, C Wu - Entropy, 2024 - mdpi.com
Variable selection methods have been extensively developed for and applied to cancer
genomics data to identify important omics features associated with complex disease traits …

BHAFT: Bayesian heredity‐constrained accelerated failure time models for detecting gene‐environment interactions in survival analysis

N Sun, J Chu, Q He, Y Wang, Q Han, N Yi… - Statistics in …, 2024 - Wiley Online Library
In addition to considering the main effects, understanding gene‐environment (G× E)
interactions is imperative for determining the etiology of diseases and the factors that affect …

The Bayesian regularized quantile varying coefficient model

F Zhou, J Ren, S Ma, C Wu - Computational Statistics & Data Analysis, 2023 - Elsevier
The quantile varying coefficient (VC) model can flexibly capture dynamical patterns of
regression coefficients. In addition, due to the quantile check loss function, it is robust …

Overlapping group screening for detection of gene-environment interactions with application to TCGA high-dimensional survival genomic data

JH Wang, KH Wang, YH Chen - BMC bioinformatics, 2022 - Springer
Background In the context of biomedical and epidemiological research, gene-environment
(GE) interaction is of great significance to the etiology and progression of many complex …

Hierarchical false discovery rate control for high-dimensional survival analysis with interactions

W Liang, Q Zhang, S Ma - Computational Statistics & Data Analysis, 2024 - Elsevier
With the development of data collection techniques, analysis with a survival response and
high-dimensional covariates has become routine. Here we consider an interaction model …

The Spike-and-Slab Quantile LASSO for Robust Variable Selection in Cancer Genomics Studies

Y Liu, J Ren, S Ma, C Wu - arXiv preprint arXiv:2405.07397, 2024 - arxiv.org
Data irregularity in cancer genomics studies has been widely observed in the form of outliers
and heavy-tailed distributions in the complex traits. In the past decade, robust variable …