Motor Neuron Disease (MND) is a fatal neurodegenerative condition, which is characterized
by the selective loss of the upper and lower motor neurons. At the sites of motor neuron …

Behçet's syndrome (BS) is a systemic vasculitis with several clinical manifestations.
Neutrophil hyperactivation mediates vascular BS pathogenesis, via both a massive reactive …

Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are
important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells …

Neuropathology studies of amyotrophic lateral sclerosis (ALS) and animal models of ALS
reveal a strong association between aberrant protein accumulation and motor neurone …

Siponimod (Mayzent®), a sphingosine 1-phosphate receptor (S1PR) modulator which
prevents lymphocyte egress from lymphoid tissues, is approved for the treatment of …

Motor neuron degeneration and neuroinflammation are the most striking pathological
features of amyotrophic lateral sclerosis (ALS). ALS currently has no cure and approved …

Since the first studies of the nervous system by the Nobel laureates Camillo Golgi and
Santiago Ramon y Cajal using simple dyes and conventional light microscopes, microscopy …

Histological identification of dispersed glioma cells in small biopsies can be challenging,
especially in tumours lacking the IDH1 R132H mutation or alterations in TP53. We …

The spectrum of background, incidental, and experimentally induced lesions affecting NSG
and NOG mice has been the subject of intense investigation. However, comprehensive …

This protocol demonstrates how to prepare primary cultures of glial cells, astrocytes, and
microglia from the cortices of Sprague Dawley rats and how to use these cells for the …